Clene to Present at Upcoming Investor Conferences

Clene Inc. (Nasdaq: CLNN) today announced that management will participate at the 5 th Annual ROTH Healthcare Opportunities Conference and at the Lytham Partners Investor Conference Fall Event and host 1x1 investor meetings at both conferences.

5 th Annual ROTH Healthcare Opportunities Conference Date: September 29, 2026 Location: New York, NY Format: 1x1 meetings 1x1 Meetings: Please contact your ROTH representative

Lytham Partners Investor Conference Fall Event Date: September 29-30, 2026 Time of Presentation: 9:45 am ET Location: Virtual Format: Presentation and 1x1 meetings 1x1 Meetings: Please contact your Lytham representative Webcast: link to webcast

A webcast of the presentation will be available on the “ Events ” section of the Clene website or using the webcast links above.

About Clene Clene Inc., (Nasdaq: CLNN) (along with its subsidiaries, “Clene”) and its wholly owned subsidiary Clene Nanomedicine Inc., is a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson’s disease, and multiple sclerosis. CNM-Au8 ® is an investigational first-in-class therapy that improves central nervous system cells’ survival and function via a mechanism that targets mitochondrial function and the NAD pathway while reducing oxidative stress. CNM-Au8 ® is a federally registered trademark of Clene Nanomedicine, Inc. The company is based in Salt Lake City, Utah, with R&D and manufacturing operations in Maryland. For more information, please visit www.clene.com or follow us on X (formerly Twitter) and LinkedIn .

Investor Contact : Kevin Gardner, LifeSci Advisors; [email protected] ; 617-283-2856 Media Contact: Caroline Wagner, FTP; [email protected] ; (267) 294-6563