VYNE Therapeutics to Participate in September Investor Conferences

VYNE Therapeutics Inc. (Nasdaq: VYNE) (“VYNE” or the “Company”), a clinical-stage biopharmaceutical company focused on developing differentiated therapies to treat chronic inflammatory and immune-mediated conditions with high unmet need, today announced that management will participate in two investor conferences in September:

H.C. Wainwright 26th Annual Global Investment Conference September 9-11, 2024, New York, NY Format: One-on-one investor meetings

Stifel 2024 Virtual Immunology and Inflammation Summit September 17-18, 2024 Presentation: Tuesday, September 17, 2024 at 8:30 AM ET Format: Fireside Chat and one-on-one investor meetings Registration: Webcast link

A webcast replay will be available on the VYNE website for 90 days following the event.

About VYNE Therapeutics Inc. VYNE is a clinical-stage biopharmaceutical company focused on developing differentiated therapies to treat chronic inflammatory and immune-mediated conditions with high unmet need. VYNE's unique and proprietary BET inhibitors, which comprise its InhiBET™ platform, are designed to overcome limitations of early generation BET inhibitors by leveraging alternative routes of administration and enhanced selectivity.

For more information about VYNE Therapeutics Inc., or its product candidates, visit www.vynetherapeutics.com. VYNE may use its website to comply with its disclosure obligations under Regulation FD. Therefore, investors should monitor VYNE’s website in addition to following its press releases, filings with the U.S. Securities and Exchange Commission, public conference calls, and webcasts.

Investor Relations: John Fraunces LifeSci Advisors, LLC 917-355-2395 [email protected]

Tyler Zeronda VYNE Therapeutics Inc. 908-458-9106 Tyler.Zeronda@VYNEtx.com