Annovis Announces Two Presentations at the CTAD 2025 Conference

Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), today announced two presentations at the 18 th Clinical Trials on Alzheimer's Disease (CTAD) conference, taking place December 1-4, 2025 in San Diego, California.

The presentations will highlight progress across the Alzheimer’s and Parkinson’s programs, with a particular focus on recent biomarker data supporting the potential disease-modifying activity of buntanetap.

Details :

Presentation #1 (P073)

Title : Amyloid co-pathology and cognitive decline in buntanetap-treated Parkinson’s disease dementia patients

Presenter : Cheng Fang, Ph.D., Senior VP, Research & Development

Time : December 1, 3:00 pm – December 2, 5:30 pm

Presentation #2 (P007)

Title : Double 6/18-month Phase 3 study to reproduce symptomatic and potentially show disease-modifying efficacy of buntanetap in treating Alzheimer’s disease

Presenter : Maria Maccecchini, Ph.D., President and CEO

Time : December 1, 3:00 pm – December 2, 5:30 pm

“We look forward to attending CTAD, which comes at the perfect moment to share our latest findings on biomarkers and cognition with the scientific community—work we believe will resonate with clinicians, researchers, and industry leaders,” said Maria Maccecchini, Ph.D., President and CEO of Annovis. “Across both disease indications, our biomarker data tell a clear story—buntanetap has the potential to address the root drivers of cognitive decline. These results not only confirm the efficacy of buntanetap seen in our earlier studies but also give us a clearer path forward as we work to bring an effective treatment to patients who urgently need better options.”

About Annovis Headquartered in Malvern, Pennsylvania, Annovis is dedicated to addressing neurodegeneration in diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The Company is committed to developing innovative therapies that improve patient outcomes and quality of life. For more information, visit www.annovisbio.com and follow us on LinkedIn , YouTube , and X .

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Forward-Looking Statements This press release contains forward-looking statements under the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended. Actual results may differ due to various risks and uncertainties, including those outlined in the Company’s SEC filings under “Risk Factors” in its Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. The Company undertakes no obligation to update forward-looking statements except as required by law.

Contact Information: Annovis Bio Inc. 101 Lindenwood Drive Suite 225 Malvern, PA 19355 www.annovisbio.com

Investor Contact: Alexander Morin, Ph.D. Director, Strategic Communications Annovis Bio [email protected] ‍