# Xenon Presents Azetukalner Phase 3 X-TOLE2 Study Results and 48-Month Long-term Data in Focal Onset Seizures at 2026 AAN Annual Meeting
Canonical URL: https://biopharmsignal.com/news/XENE/xenon-presents-azetukalner-phase-3-x-tole2-study-results-and-48-month-long-term-data-in-focal-onset-seizures-at-2026-aan-annual-meeting
Ticker: XENE
Company: Xenon
Source: Xenon
Published: 2026-04-19 22:00 EST
Original Source URL: https://investor.xenon-pharma.com
## Summary

Azetukalner data show significant reductions in seizure frequency across weekly, monthly and multi-year time points X-TOLE2 data featured in Late-breaking Science session show 53.2% reduction in monthly seizure frequency in 25 mg group vs. 10.4% for placebo and increasing rates of 100% seizure

## Article Body
Azetukalner data show significant reductions in seizure frequency across weekly, monthly and multi-year time points X-TOLE2 data featured in Late-breaking Science session show 53.2% reduction in monthly seizure frequency in 25 mg group vs. 10.4% for placebo and increasing rates of 100% seizure
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- 2026-04-19 22:00 EST — [Results from the Phase 3 X-TOLE2 Study Evaluating Azetukalner, a Novel, Potent KV7 Channel Opener, in Adults With Focal Onset Seizures (FOS)](https://biopharmsignal.com/news/XENE/results-from-the-phase-3-x-tole2-study-evaluating-azetukalner-a-novel-potent-kv7-channel-opener-in-adults-with-focal-onset-seizures-fos) — Source: Xenon
- 2026-04-19 22:00 EST — [Xenon Presents Azetukalner Phase 3 X-TOLE2 Study Results and 48-Month Long-term Data in Focal Onset Seizures at 2026 AAN Annual Meeting](https://biopharmsignal.com/news/XENE/xenon-presents-azetukalner-phase-3-x-tole2-study-results-and-48-month-long-term-data-in-focal-onset-seizures-at-2026-aan-annual-meeting) — Source: Xenon
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