# Positive Interim Data from Cohorts 1 and 2 of Tenaya’s RIDGE™-1 Phase 1b/2 Clinical Trial of TN-401 Demonstrated Consistent Reductions in Arrhythmia Burden for Adults with PKP2-associated ARVC
Canonical URL: https://biopharmsignal.com/news/TNYA/positive-interim-data-from-cohorts-1-and-2-of-tenaya-s-ridgetm-1-phase-1b-2-clinical-trial-of-tn-401-demonstrated-consistent-reductions-in-arrhythmia-burden-for-adults-with-pkp2-associated-arvc
Ticker: TNYA
Company: Tenaya Therapeutics
Source: Tenaya Therapeutics
Published: 2026-05-15 10:01 EST
Original Source URL: https://investors.tenayatherapeutics.com
## Summary

All Patients Achieved Meaningful Decreases (Mean = 64%) in Daily Premature Ventricular Contraction Count  TN-401 Gene Therapy was Well Tolerated at 3E13 vg/kg and 6E13 vg/kg Doses Post-dose Biopsies Provide Evidence of TN-401 Activity in Heart Muscle Cells PRIME Designation Granted by European

## Article Body
All Patients Achieved Meaningful Decreases (Mean = 64%) in Daily Premature Ventricular Contraction Count  TN-401 Gene Therapy was Well Tolerated at 3E13 vg/kg and 6E13 vg/kg Doses Post-dose Biopsies Provide Evidence of TN-401 Activity in Heart Muscle Cells PRIME Designation Granted by European
## Recent Company News
- 2026-06-03 11:00 EST — [Tenaya Therapeutics Announces Interim Data from MyPEAK™-1 Showing Treatment of MYBPC3-associated HCM with TN-201 Gene Therapy Resulted in Consistent Signs of Cardiac Remodeling and Reductions in Symptoms](https://biopharmsignal.com/news/TNYA/tenaya-therapeutics-announces-interim-data-from-mypeaktm-1-showing-treatment-of-mybpc3-associated-hcm-with-tn-201-gene-therapy-resulted-in-consistent-signs-of-cardiac-remodeling-and-reductions-in-symptoms) — Source: Tenaya Therapeutics
- 2026-06-02 20:30 EST — [Tenaya Therapeutics to Announce New Interim Data from MyPEAK™-1 Phase 1b/2 Trial of TN-201 for Adults with MYBPC3-Associated HCM on Wednesday, June 3, 2026](https://biopharmsignal.com/news/TNYA/tenaya-therapeutics-to-announce-new-interim-data-from-mypeaktm-1-phase-1b-2-trial-of-tn-201-for-adults-with-mybpc3-associated-hcm-on-wednesday-june-3-2026) — Source: Tenaya Therapeutics
- 2026-05-29 12:00 EST — [Tenaya Therapeutics to Participate in the Jefferies Global Healthcare Conference 2026](https://biopharmsignal.com/news/TNYA/tenaya-therapeutics-to-participate-in-the-jefferies-global-healthcare-conference-2026) — Source: Tenaya Therapeutics
- 2026-05-15 10:01 EST — [Positive Interim Data from Cohorts 1 and 2 of Tenaya’s RIDGE™-1 Phase 1b/2 Clinical Trial of TN-401 Demonstrated Consistent Reductions in Arrhythmia Burden for Adults with PKP2-associated ARVC](https://biopharmsignal.com/news/TNYA/positive-interim-data-from-cohorts-1-and-2-of-tenaya-s-ridgetm-1-phase-1b-2-clinical-trial-of-tn-401-demonstrated-consistent-reductions-in-arrhythmia-burden-for-adults-with-pkp2-associated-arvc) — Source: Tenaya Therapeutics
- 2026-05-06 20:05 EST — [Tenaya Therapeutics Reports First Quarter 2026 Financial Results and Provides Business Update](https://biopharmsignal.com/news/TNYA/tenaya-therapeutics-reports-first-quarter-2026-financial-results-and-provides-business-update) — Source: Tenaya Therapeutics
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