# Innate Pharma announces Completion of Enrollment in Phase 1 Dose Escalation Study of IPH4502, a Novel Nectin-4 Exatecan Antibody-Drug Conjugate (ADC) Canonical URL: https://biopharmsignal.com/news/IPHA/innate-pharma-announces-completion-of-enrollment-in-phase-1-dose-escalation-stud-0778493f Ticker: IPHA Company: Innate Pharma Source: Innate Pharma Published: 2026-07-20 14:53 EST Original Source URL: https://www.innate-pharma.com/media/all-press-releases/innate-pharma-announces-completion-enrollment-phase-1-dose-escalation-study-iph4502-novel-nectin-4-exatecan-antibody-drug-conjugate-adc ## Summary Tue, 07/21/2026 - 07:00 Enrollment completed in the dose escalation of IPH4502-101 study, with preliminary data readout from 76 patients expected by year-endFavorable safety profile observed to dat... ## Article Body Tue, 07/21/2026 - 07:00 Enrollment completed in the dose escalation of IPH4502-101 study, with preliminary data readout from 76 patients expected by year-end Favorable safety profile observed to date, with limited hematological toxicity Objective responses observed in heavily pre-treated patients with post-EV UC, as well as NSCLC and HNSCC, supporting the potential of IPH4502 in populations with high unmet medical need Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) ("Innate" or the "Company"), today announced the completion of enrollment in the dose escalation of the Phase 1 study of IPH4502 ( NCT06781983 ), its proprietary Nectin-4 exatecan ADC. Preliminary data are expected by year-end and will include data from 76 patients, guiding Phase 1 dose optimization in selected tumor types. The IPH4502-101 Phase 1 study is an open-label, multi-center study evaluating the safety, tolerability, and preliminary anti-tumor activity of IPH4502 as a single agent in patients with advanced solid tumors known to express Nectin-4, including but not limited to urothelial carcinoma (UC), non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), breast, ovarian, gastric, esophageal, and colorectal cancers. The Phase 1 dose-escalation part has recruited 76 patients in France and the United States. To date, IPH4502 continues to show a favorable safety profile, with limited hematological toxicity, supporting the hypothesis that the Company’s proprietary linker leads to a slow release of free exatecan, minimizing toxicity. Preliminary anti-tumor activity continues to be observed in heavily pre-treated patients with advanced solid tumors, with objective responses reported in UC post enfortumab vedotin, as well as in NSCLC and HNSCC. “ Completing enrollment in the dose escalation marks an important milestone for IPH4502. The data generated to date continue to support the differentiated design of IPH4502, notably through the limited hematological toxicity observed to date, which we believe might reflect the benefits of our proprietary linker. We look forward to the dose escalation dataset by year-end, which will guide our path into dose optimization and further define the clinical potential of IPH4502 ,” said Sonia Quaratino, EVP Chief Medical Officer of Innate Pharma. About IPH4502 IPH4502 is Innate Pharma's proprietary Nectin-4 antibody-drug conjugate (ADC), built on three differentiated components. The payload is exatecan, a potent topoisomerase I inhibitor, with the potential to overcome key limitations associated with monomethyl auristatin E (MMAE)-based ADCs, including multidrug resistance protein 1 (MDR1)-mediated resistance, and without the need for CYP2D6 genotyping. IPH4502 incorporates a proprietary stable linker designed to slow the release of free exatecan into the circulation. The binder is a proprietary humanized anti-Nectin-4 antibody with high affinity and a distinct, non-overlapping epitope compared with enfortumab vedotin (EV). In preclinical studies, IPH4502 demonstrated anti-tumor activity in EV-resistant tumor models and in tumors with low and heterogeneous Nectin-4 expression, supporting its potential applicability across solid tumor types beyond urothelial carcinoma (UC). IPH4502 is currently being evaluated in the Phase 1 IPH4502-101 study ( NCT06781983 ) in patients with advanced solid tumors known to express Nectin-4. ## Recent Company News - 2026-07-20 14:53 EST — [Innate Pharma announces Completion of Enrollment in Phase 1 Dose Escalation Study of IPH4502, a Novel Nectin-4 Exatecan Antibody-Drug Conjugate (ADC)](https://biopharmsignal.com/news/IPHA/innate-pharma-announces-completion-of-enrollment-in-phase-1-dose-escalation-stud-0778493f) — Source: Innate Pharma - 2026-06-25 13:46 EST — [Outcome of Innate Pharma’s 2026 Annual General Meeting](https://biopharmsignal.com/news/IPHA/outcome-of-innate-pharma-s-2026-annual-general-meeting) — Source: Innate Pharma - 2026-06-25 13:46 EST — [Innate Pharma to participate in the Jefferies Global Healthcare Conference](https://biopharmsignal.com/news/IPHA/innate-pharma-to-participate-in-the-jefferies-global-healthcare-conference) — Source: Innate Pharma - 2026-06-25 13:46 EST — [Innate Pharma Reports First Quarter 2026 Business Update and Financial Results](https://biopharmsignal.com/news/IPHA/innate-pharma-reports-first-quarter-2026-business-update-and-financial-results) — Source: Innate Pharma - 2026-06-25 13:46 EST — [Number of shares and voting rights of Innate Pharma as of April 16, 2026](https://biopharmsignal.com/news/IPHA/number-of-shares-and-voting-rights-of-innate-pharma-as-of-april-16-2026) — Source: Innate Pharma ## Related News - 2026-07-21 12:05 EST — VRCA — [Verrica Pharmaceuticals and Medomie Pharma Enter into Exclusive Distribution, Marketing and Supply Agreement to Commercialize YCANTH® for the Treatment of Molluscum Contagiosum in Israel](https://biopharmsignal.com/news/VRCA/verrica-pharmaceuticals-and-medomie-pharma-enter-into-exclusive-distribution-mar-abf61522) - 2026-07-21 12:00 EST — ACON — [Aclarion Announces Presentation of Two Abstracts Highlighting Nociscan's Growing Role in Real-World Clinical Practice](https://biopharmsignal.com/news/ACON/aclarion-announces-presentation-of-two-abstracts-highlighting-nociscan-s-growing-1db0bde9) - 2026-07-21 12:00 EST — MOR — [Novartis delivered sales growth in Q2 and further advanced the pipeline; Full-year guidance reaffirmed](https://biopharmsignal.com/news/MOR/novartis-delivered-sales-growth-in-q2-and-further-advanced-the-pipeline-full-yea-63a32b47) - 2026-07-21 11:30 EST — ABEO — [Cincinnati Children's Activated as the Seventh Qualified Treatment Center for ZEVASKYN®](https://biopharmsignal.com/news/ABEO/cincinnati-children-s-activated-as-the-seventh-qualified-treatment-center-for-ze-8382d043) - 2026-07-21 11:00 EST — KTTA — [Pasithea Therapeutics Announces Presentation of PAS-004 Data to European Society for Medical Oncology (ESMO) Congress 2026](https://biopharmsignal.com/news/KTTA/pasithea-therapeutics-announces-presentation-of-pas-004-data-to-european-society-99db076a)