# Aprea Therapeutics Announces Early Clinical Proof-Of-Concept in the Ongoing ACESOT-1051 Dose-Escalation Trial Evaluating WEE1 Inhibitor APR-1051, Including Partial Response Observed on First Scan
Canonical URL: https://biopharmsignal.com/news/APRE/aprea-therapeutics-announces-early-clinical-proof-of-concept-in-the-ongoing-acesot-1051-dose-escalation-trial-evaluating-wee1-inhibitor-apr-1051-including-partial-response-observed-on-first-scan
Ticker: APRE
Company: Aprea Therapeutics
Source: Aprea Therapeutics
Published: 2026-01-29 13:27 EST
Original Source URL: https://ir.aprea.com
## Summary

Approximately 50% reduction in target lesion and greater than 90% decrease in CA-125 observed in endometrial cancer patient The unconfirmed partial response (uPR) that was observed in the first scan has been achieved at the 150 mg dose, with 220 mg cohort currently enrolling in the ACESOT-1051

## Article Body
Approximately 50% reduction in target lesion and greater than 90% decrease in CA-125 observed in endometrial cancer patient The unconfirmed partial response (uPR) that was observed in the first scan has been achieved at the 150 mg dose, with 220 mg cohort currently enrolling in the ACESOT-1051
## Recent Company News
- 2026-06-01 12:00 EST — [Aprea Therapeutics Presents Updated Phase 1 Data on WEE1 Inhibitor APR-1051 at ASCO 2026, Demonstrating Early Monotherapy Activity and Manageable Tolerability in Advanced Solid Tumors](https://biopharmsignal.com/news/APRE/aprea-therapeutics-presents-updated-phase-1-data-on-wee1-inhibitor-apr-1051-at-asco-2026-demonstrating-early-monotherapy-activity-and-manageable-tolerability-in-advanced-solid-tumors) — Source: Aprea Therapeutics
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- 2026-04-21 14:15 EST — [Aprea Therapeutics to Provide Clinical Update on ACESOT-1051 Phase 1 Trial Evaluating WEE1 Inhibitor, APR-1051, at ASCO 2026 Annual Meeting](https://biopharmsignal.com/news/APRE/aprea-therapeutics-to-provide-clinical-update-on-acesot-1051-phase-1-trial-evaluating-wee1-inhibitor-apr-1051-at-asco-2026-annual-meeting) — Source: Aprea Therapeutics
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- 2026-03-30 12:01 EST — [Aprea Therapeutics Announces Oversubscribed $30 Million Private Placement](https://biopharmsignal.com/news/APRE/aprea-therapeutics-announces-oversubscribed-30-million-private-placement) — Source: Aprea Therapeutics
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