# Amarin Highlights New REDUCE-IT® and Mechanistic Data Presented at European Society of Cardiology (ESC) Congress 2026 Canonical URL: https://biopharmsignal.com/news/AMRN/amarin-highlights-new-reduce-it-and-mechanistic-data-presented-at-european-socie-1ffb63d9 Ticker: AMRN Company: Amarin Corporation Source: Amarin Corporation Published: 2026-08-31 12:15 EST ## Summary Presentations Expand Understanding of Treatment Adherence, Long-Term Outcomes, Lipoprotein(a), Coagulation Biomarkers, and Potential Mechanisms of... ## Article Body Presentations Expand Understanding of Treatment Adherence, Long-Term Outcomes, Lipoprotein(a), Coagulation Biomarkers, and Potential Mechanisms of Eicosapentaenoic Acid (EPA) 2026 ESC/ European Renal Association (ERA) Cardiova scular and Chronic Kidney Disease Guideline Further Reinforces the Clinical Evidence Supporting Icosapent Ethyl DUBLIN and BRIDGEWATER, N.J., Aug. 31, 2026 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN), a company committed to advancing the science of cardiovascular disease (CVD) worldwide, today highlighted findings from multiple Amarin supported presentations at the European Society of Cardiology (ESC) Congress 2026 in Munich, Germany. The research presented by leading academic collaborators further expanded understanding of treatment adherence, long-term cardiovascular outcomes, lipoprotein(a) [Lp(a)] biology, coagulation biomarkers and potential mechanistic pathways associated with eicosapentaenoic acid (EPA) and icosapent ethyl (IPE). The presentations build upon the significant body of evidence generated from REDUCE-IT and related scientific investigations. "The research presented at ESC Congress 2026 demonstrates the continued scientific value of REDUCE-IT and the breadth of insights that can be gained through ongoing clinical and mechanistic investigation," said Deepak L. Bhatt, M.D., M.P.H., M.B.A., Director of Mount Sinai Fuster Heart Hospital and the Dr. Valentin Fuster Professor of Medicine at the Icahn School of Medicine at Mount Sinai. "These studies advance our understanding of important factors that influence residual cardiovascular risk, including lipoprotein(a) biology, treatment adherence, sex-related differences in study participation, and coagulation pathways. At the same time, mechanistic research continues to provide new insights into how EPA may favorably influence biological processes associated with cardiovascular disease. Despite meaningful progress in cardiovascular prevention, substantial residual risk remains for many patients, underscoring the importance of utilizing proven, complementary therapies as part of a comprehensive treatment strategy. Collectively, these findings further strengthen the body of scientific evidence supporting the role of icosapent ethyl in helping reduce cardiovascular risk in appropriately selected patients." In addition, the recently published 2026 dedicated ESC Guidelines for the Management of Cardiovascular Disease and Chronic Kidney Disease, developed with the ERA, recognize evidence from the REDUCE-IT RENAL publication showing that icosapent ethyl reduced major adverse cardiovascular events in statin-treated patients with established ASCVD, elevated triglycerides, and chronic kidney disease. i Relative risk reductions were consistent across subgroups divided by estimated glomerular filtration rate (eGFR) at baseline, with absolute benefits largest in patients with eGFR 1% more frequent than placebo): arthralgia (2% vs 1%) and oropharyngeal pain (1% vs 0.3%). Adverse events may be reported by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088. Patients receiving VASCEPA and concomitant anticoagulants and/or anti-platelet agents should be monitored for bleeding. FULL U.S. FDA-APPROVED VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM . Europe For further information about the Summary of Product Characteristics (SmPC) for VAZKEPA ® in Europe, please visit: https://www.ema.europa.eu/en/documents/product-information/vazkepa-epar-product-information_en.pdf Globally, prescribing information varies; refer to the individual country product label for complete information. Forward-Looking Statements This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including beliefs about Amarin’s outlook for achievements in 2026 and beyond; Amarin’s overall efforts to expand access and reimbursement to VASCEPA/VAZKEPA across global markets; expectations regarding potential market dynamics, payer behavior, and the competitive landscape; and the overall potential and future success of VASCEPA/VAZKEPA and Amarin that are based on the beliefs and assumptions and information currently available to Amarin. All statements other than statements of historical fact contained in this press release are forward-looking statements. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin’s filings with the U.S. Securities and Exchange Commission, including Amarin’s annual report on Form 10-K for the fiscal year ended 2025 and subsequent quarterly reports on Form 10-Q. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. Amarin undertakes no obligation to update or revise the information contained in its forward-looking statements, whether as a result of new information, future events or circumstances or otherwise. Amarin Contact Information Media Inquiries: Amarin Corporation plc PR@amarincorp.com Investor Inquiries: Devin Sullivan & Conor Rodriguez The Equity Group on Behalf of Amarin devin.sullivan.ext@amarincorp.com or conor.rodriguez.ext@amarincorp.com Investor.relations@amarincorp.com ___________________________ i 2026 ESC Guidelines for the management of cardiovascular disease and chronic kidney disease. Eur Heart J. 2026. doi:10.1093/eurheartj/ehag098. ii Bhatt DL, Steg PG, Brinton E, et al., on behalf of the REDUCE-IT Investigators. Rationale and Design of REDUCE‐IT: Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial. Clin Cardiol. 2017;40:138-148. iii Bhatt DL, Steg PG, Miller M, et al., on behalf of the REDUCE-IT Investigators. Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia. N Engl J Med. 2019;380:11-22. DOI: 10.1056/NEJMoa1812792 iv Bhatt DL, Steg PG, Miller M, et al., on behalf of the REDUCE-IT Investigators. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT. J Am Coll Cardiol. 2019;73:2791-2802. ## Recent Company News - 2026-08-31 12:15 EST — [Amarin Highlights New REDUCE-IT® and Mechanistic Data Presented at European Society of Cardiology (ESC) Congress 2026](https://biopharmsignal.com/news/AMRN/amarin-highlights-new-reduce-it-and-mechanistic-data-presented-at-european-socie-1ffb63d9) — Source: Amarin Corporation - 2026-08-28 12:15 EST — [New REDUCE-IT® Legacy Analysis Presented at European Society of Cardiology (ESC) Congress 2026 Suggests Persistent Cardiovascular Benefit Following Icosapent Ethyl Treatment Cessation in Adherent Patients](https://biopharmsignal.com/news/AMRN/new-reduce-it-legacy-analysis-presented-at-european-society-of-cardiology-esc-co-9ceb1716) — Source: Amarin Corporation - 2026-08-24 12:15 EST — [New Analyses from REDUCE-IT® and EPA Mechanistic Data to be Presented at the European Society of Cardiology (ESC) Congress 2026](https://biopharmsignal.com/news/AMRN/new-analyses-from-reduce-it-and-epa-mechanistic-data-to-be-presented-at-the-euro-2999f8d7) — Source: Amarin Corporation - 2026-07-29 11:00 EST — [Amarin Reports 2026 Second Quarter Financial Results Demonstrating Early Success of Fully Partnered International Commercial Strategy and Continued Leading U.S. Market Presence](https://biopharmsignal.com/news/AMRN/amarin-reports-2026-second-quarter-financial-results-demonstrating-early-success-f75796f5) — Source: Amarin Corporation - 2026-07-15 12:00 EST — [Amarin to Report Second Quarter 2026 Financial Results and Host Conference Call on July 29, 2026](https://biopharmsignal.com/news/AMRN/amarin-to-report-second-quarter-2026-financial-results-and-host-conference-call--e5f8b443) — Source: Amarin Corporation ## Related News - 2026-09-06 05:00 EST — ROIV — [Roivant to Present Topline Results from the Phase 2 PHocus Study of Mosliciguat in Patients with Pulmonary Hypertension Associated with Interstitial Lung Disease (PH-ILD) at the ERS Congress 2026 on Tuesday, September 8, 2026, and Host Investor Call](https://biopharmsignal.com/news/ROIV/roivant-to-present-topline-results-from-the-phase-2-phocus-study-of-mosliciguat--bf1ea553) - 2026-09-04 20:30 EST — ORIC — [ORIC Pharmaceuticals Reports Inducement Grants under Nasdaq Listing Rule 5635(c)(4)](https://biopharmsignal.com/news/ORIC/oric-pharmaceuticals-reports-inducement-grants-under-nasdaq-listing-rule-5635-c--e23953dd) - 2026-09-04 20:05 EST — RPID — [Rapid Micro Biosystems to Participate in Upcoming Investor Conferences](https://biopharmsignal.com/news/RPID/rapid-micro-biosystems-to-participate-in-upcoming-investor-conferences-91a8800f) - 2026-09-04 20:05 EST — LIXT — [NOMAD POWER SOLUTIONS ANNOUNCES ADJOURNMENT OF SPECIAL MEETING OF STOCKHOLDERS](https://biopharmsignal.com/news/LIXT/nomad-power-solutions-announces-adjournment-of-special-meeting-of-stockholders-74cd9e2e) - 2026-09-04 20:05 EST — AVTX — [Avalo Therapeutics Announces Inducement Grants to New Employees Under Nasdaq Listing Rule 5635(c)(4)](https://biopharmsignal.com/news/AVTX/avalo-therapeutics-announces-inducement-grants-to-new-employees-under-nasdaq-lis-cc7baaf2)